采用反相高效液相色谱法测定生物材料中乏氧细胞增敏剂米索硝唑及其O-去甲基代谢物。 - Suppr

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超能文献

Estimation of the hypoxic cell-sensitiser misonidazole and its O-demethylated metabolite in biological materials by reversed-phase high-performance liquid chromatography.

作者信息

Workman P, Little C J, Marten T R, Dale A D, Ruane R J, Flockhart I R, Bleehen N M

出版信息

J Chromatogr. 1978 May 1;145(3):507-12. doi: 10.1016/s0378-4347(00)81386-9.

DOI:10.1016/s0378-4347(00)81386-9

PMID:659541

Abstract

摘要

相似文献

Estimation of the hypoxic cell-sensitiser misonidazole and its O-demethylated metabolite in biological materials by reversed-phase high-performance liquid chromatography.采用反相高效液相色谱法测定生物材料中乏氧细胞增敏剂米索硝唑及其O-去甲基代谢物。

J Chromatogr. 1978 May 1;145(3):507-12. doi: 10.1016/s0378-4347(00)81386-9.

The radiosensitizer Ro 03-8799 and the concentrations which may be achieved in human tumours: a preliminary study.放射增敏剂Ro 03 - 8799及其在人类肿瘤中可能达到的浓度：一项初步研究。

Br J Cancer. 1982 Nov;46(5):706-10. doi: 10.1038/bjc.1982.262.

A phase I study of the combined hypoxic cell radiosensitizers, Ro 03-8799 and SR 2508: a preliminary report of single-dose toxicity, pharmacokinetics and tumour concentrations.低氧细胞放射增敏剂Ro 03-8799与SR 2508联合应用的I期研究：单剂量毒性、药代动力学及肿瘤浓度的初步报告

Br J Radiol. 1986 Apr;59(700):423-5. doi: 10.1259/0007-1285-59-700-423.

Gradient high-performance liquid chromatographic method for simultaneous assay of the radiosensitizers etanidazole (SR 2508) and pimonidazole (Ro 03-8799) in biological materials.梯度高效液相色谱法同时测定生物材料中的放射增敏剂依他硝唑（SR 2508）和匹莫硝唑（Ro 03 - 8799）

J Chromatogr. 1987 Sep 4;420(1):223-7. doi: 10.1016/0378-4347(87)80178-0.

Clinical studies with misonidazole.米索硝唑的临床研究。

Br J Cancer Suppl. 1978 Jun;3:286-9.

A drug for improved radiosensitization in radiotherapy.一种用于改善放射治疗中放射增敏作用的药物。

Br J Cancer. 1980 Jul;42(1):153-5. doi: 10.1038/bjc.1980.213.

The clinical testing of Ro 03-8799--pharmacokinetics, toxicology, tissue and tumor concentrations.Ro 03 - 8799的临床试验——药代动力学、毒理学、组织及肿瘤浓度

Int J Radiat Oncol Biol Phys. 1984 Sep;10(9):1759-63. doi: 10.1016/0360-3016(84)90544-3.

A phase I study of the hypoxic cell radiosensitizer Ro-03-8799.乏氧细胞放射增敏剂Ro-03-8799的I期研究。

Int J Radiat Oncol Biol Phys. 1984 Sep;10(9):1755-8. doi: 10.1016/0360-3016(84)90543-1.

Pharmacokinetic and metabolic studies of the hypoxic cell radiosensitizer misonidazole.乏氧细胞放射增敏剂米索硝唑的药代动力学和代谢研究。

Xenobiotica. 1978 Feb;8(2):97-105. doi: 10.3109/00498257809060388.

Comparison of the fate of misonidazole (RO 07-0582) and its metabolite desmethylmisonidazole (RO 05-9963), two hypoxic cell radiosensitizers: penetration properties in tumor bearing rats.两种乏氧细胞放射增敏剂米索硝唑（RO 07-0582）及其代谢产物去甲基米索硝唑（RO 05-9963）的转归比较：在荷瘤大鼠体内的渗透特性

J Pharmacol. 1983 Jan-Mar;14(1):67-77.

引用本文的文献

Dose-dependence and related studies on the pharmacokinetics of misonidazole and desmethylmisonidazole in mice.米索硝唑和去甲基米索硝唑在小鼠体内的药代动力学剂量依赖性及相关研究

Cancer Chemother Pharmacol. 1980;5(1):27-37. doi: 10.1007/BF00578559.

In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: methotrexate, 5-fluorouracil and adriamycin.抗癌药物与米索硝唑或甲硝唑在体内的相互作用：甲氨蝶呤、5-氟尿嘧啶和阿霉素。

Br J Cancer. 1980 Dec;42(6):861-70. doi: 10.1038/bjc.1980.334.

Effects of local hyperthermia on the pharmacokinetics of misonidazole in the anaesthetized mouse.局部热疗对麻醉小鼠体内米索硝唑药代动力学的影响。

Br J Cancer. 1980 Apr;41(4):529-40. doi: 10.1038/bjc.1980.95.

Phenytoin shortens the half-life of the hypoxic cell radiosensitizer misonidazole in man: implications for possible reduced toxicity.苯妥英钠可缩短人体中缺氧细胞放射增敏剂米索硝唑的半衰期：对可能降低毒性的意义。

Br J Cancer. 1980 Feb;41(2):302-4. doi: 10.1038/bjc.1980.43.

Pharmacokinetic and tumour-penetration properties of the hypoxic cell radiosensitizer desmethylmisonidazole (Ro 05-Ro-9963) in dogs.乏氧细胞放射增敏剂去甲基米索硝唑（Ro 05-Ro-9963）在犬体内的药代动力学及肿瘤穿透特性

Br J Cancer. 1980 Feb;41(2):268-76. doi: 10.1038/bjc.1980.39.

Phenytoin-induced changes in the pharmacokinetics of misonidazole in radiotherapy patients.苯妥英钠对放疗患者米索硝唑药代动力学的影响。

Br J Cancer. 1981 Oct;44(4):592-6. doi: 10.1038/bjc.1981.232.

Structure-pharmacokinetic relationships for misonidazole analogues in mice.米索硝唑类似物在小鼠体内的结构-药代动力学关系

Cancer Chemother Pharmacol. 1981;6(1):39-49. doi: 10.1007/BF00253009.

Absorption and distribution of vaginally administered misonidazole.阴道给药米索硝唑的吸收与分布。

Cancer Chemother Pharmacol. 1982;9(2):118-9. doi: 10.1007/BF00265391.

Effect of clinical levels of misonidazole on the response of tumour and normal tissues in the mouse to alkylating agents.米索硝唑临床剂量对小鼠肿瘤及正常组织对烷化剂反应的影响。

Br J Cancer. 1982 May;45(5):700-8. doi: 10.1038/bjc.1982.111.

The penetration of misonidazole into a mature structural cartilage.米索硝唑在成熟结构软骨中的渗透情况。

Br J Cancer. 1982 Feb;45(2):282-5. doi: 10.1038/bjc.1982.44.

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