Workman P, Wiltshire C R, Plowman P N, Bleehen N M
Br J Cancer. 1978 Dec;38(6):709-18. doi: 10.1038/bjc.1978.277.
Concentrations of misonidazole and its O-demethylated metabolite Ro 05-9963 in the plasma and saliva of 10 patients with malignant disease have been determined. A good linear correlation was established between plasma and saliva misonidazole concentration, and salivary sampling was found to be suitable for the estimation of a number of pharmacokinetic parameters. Data are also presented for serial tumour cencentrations of misonidazole and Ro 05-9963 in 3 of the 10 patients. Monitoring of salivary misonidazole concentration appears to be a useful alternative to plasma monitoring, particularly for those patients in whom plasma sampling is unsuitable or impossible.
已测定10例恶性疾病患者血浆和唾液中米索硝唑及其O-去甲基代谢物Ro 05-9963的浓度。血浆和唾液中米索硝唑浓度之间建立了良好的线性相关性，并且发现唾液采样适用于估算多个药代动力学参数。还给出了10例患者中3例的米索硝唑和Ro 05-9963的系列肿瘤浓度数据。监测唾液中米索硝唑浓度似乎是血浆监测的一种有用替代方法，特别是对于那些血浆采样不合适或不可能的患者。
