Kahl R
Cancer Lett. 1980 Feb;8(4):323-8. doi: 10.1016/0304-3835(80)90148-2.
Enhancement of pulmonary epoxide hydratase activity in the rat was obtained by feeding a diet which contained 0.5% ethoxyquin (EQ) or 3,5-di-tert-butyl-4-hydroxytoluene (BHT). The enhancement was less marked (1.6-fold) than in the liver, where a 2-4-fold enhancement of enzyme activity was found after feeding 0.5% antioxidant. A minimal enhancing concentration of 0.1% EQ or BHT in food was established for hepatic epoxide hydratase. In kidney microsomes, elevation of enzyme activity was obtained with 0.5% EQ (1.8-fold), but not with 0.5% BHT. No concomitant increase of cytochrome P-450 content and of aryl hydrocarbon hydroxylase activity was found in the tissues studied.
通过喂食含有0.5%乙氧喹（EQ）或3,5-二叔丁基-4-羟基甲苯（BHT）的饮食，可提高大鼠肺中环氧水解酶的活性。这种提高不如肝脏中明显（1.6倍），在肝脏中，喂食0.5%抗氧化剂后酶活性提高了2至4倍。确定食物中EQ或BHT提高肝脏环氧水解酶活性的最低浓度为0.1%。在肾脏微粒体中，0.5%的EQ可使酶活性升高（1.8倍），但0.5%的BHT则不能。在所研究的组织中，未发现细胞色素P-450含量和芳烃羟化酶活性同时增加。
