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甲氧苄啶可增强萘啶酸和恶喹酸的抗菌活性,并延缓耐药性的出现。

Trimethoprim enhances the antibacterial activity of nalidixic and oxolinic acids and delays the emergence of resistance.

作者信息

Bertolini A, Castelli M, Genedani S, Garuti M

出版信息

Experientia. 1980 Feb 15;36(2):243-4. doi: 10.1007/BF01953757.

DOI:10.1007/BF01953757
PMID:7371772
Abstract

Trimethoprim enhances the in vitro activity of nalidixic and oxolinic acids against some representative pathogenic microorganisms, including those which are most frequently responsible for urinary tract infections, and delays the emergence of resistance in many of them.

摘要

甲氧苄啶可增强萘啶酸和恶喹酸对一些代表性致病微生物的体外活性,这些微生物包括那些最常引起尿路感染的病原体,并且能延缓其中许多微生物耐药性的出现。

相似文献

1
Trimethoprim enhances the antibacterial activity of nalidixic and oxolinic acids and delays the emergence of resistance.甲氧苄啶可增强萘啶酸和恶喹酸的抗菌活性,并延缓耐药性的出现。
Experientia. 1980 Feb 15;36(2):243-4. doi: 10.1007/BF01953757.
2
In vitro activity of oxolinic acid and nalidixic acid against common urinary pathogens: a comparative study.恶喹酸和萘啶酸对常见尿路病原体的体外活性:一项比较研究。
Curr Med Res Opin. 1978;5(9):743-8. doi: 10.1185/03007997809110216.
3
Activity of flumequine against Escherichia coli: in vitro comparison with nalidixic and oxolinic acids.氟甲喹对大肠杆菌的活性:与萘啶酸和恶喹酸的体外比较。
Antimicrob Agents Chemother. 1978 Mar;13(3):479-83. doi: 10.1128/AAC.13.3.479.
4
[In vitro action of oxolinic acid in comparison with nitrofurantoin and nalidixic acid].[恶喹酸与呋喃妥因和萘啶酸的体外作用比较]
Minerva Urol. 1977 Sep-Oct;29(5):225-7.
5
[Comparison of antibacterial activity of oxolinic acid (Gramurin) and nalidixic acid (Nevigramon) in vitro and in patients with urinary tract infections].
Pol Tyg Lek. 1978 Aug 21;33(34):1347-50.
6
Cross resistance of quinolone derivatives in gram-negative bacteria.革兰氏阴性菌中喹诺酮衍生物的交叉耐药性。
Chemioterapia. 1985 Apr;4(2):192-6.
7
Comparative in vitro studies of nalidixic acid, oxolinic acid, and a new analog with thieno (2,3-b) pyridine structure.萘啶酸、恶喹酸及一种具有噻吩并(2,3 - b)吡啶结构的新类似物的体外比较研究
Antimicrob Agents Chemother. 1978 Mar;13(3):533-5. doi: 10.1128/AAC.13.3.533.
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[Minimal inhibitory concentration in hospital bacteria].[医院细菌中的最低抑菌浓度]
Rev Asoc Argent Microbiol. 1974 May-Aug;6(2):44-61.
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[Comparative study of six quinolone antibacterials (author's transl)].六种喹诺酮类抗菌药物的比较研究(作者译)
Ann Microbiol (Paris). 1977 Jul;128B(1):19-33.
10
Letter: Oxolinic acid in urinary infections.信函:恶喹酸在泌尿系统感染中的应用。
Lancet. 1974 Nov 2;2(7888):1088-9. doi: 10.1016/s0140-6736(74)92200-4.

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Antibiotic resistome of Salmonella typhi: molecular determinants for the emergence of drug resistance.伤寒沙门氏菌的抗生素耐药组:耐药性出现的分子决定因素。
Front Med. 2021 Oct;15(5):693-703. doi: 10.1007/s11684-020-0777-6. Epub 2021 Jun 4.
2
Synergism of trimethoprim and ciprofloxacin in vitro against clinical bacterial isolates.甲氧苄啶与环丙沙星对临床分离细菌的体外协同作用。
Eur J Clin Microbiol Infect Dis. 1992 Mar;11(3):255-7. doi: 10.1007/BF02098092.

本文引用的文献

1
MECHANISM OF ACTION OF NALIDIXIC ACID ON ESCHERICHIA COLI.II. INHIBITION OF DEOXYRIBONUCLEIC ACID SYNTHESIS.萘啶酸对大肠杆菌的作用机制。二、脱氧核糖核酸合成的抑制
J Bacteriol. 1965 Apr;89(4):1068-74. doi: 10.1128/jb.89.4.1068-1074.1965.
2
MECHANISM OF ACTION OF NALIDIXIC ACID ON ESCHERICHIA COLI.萘啶酸对大肠杆菌的作用机制
J Bacteriol. 1964 Oct;88(4):1112-8. doi: 10.1128/jb.88.4.1112-1118.1964.
3
TREATMENT OF URINARY TRACT INFECTION WITH NALIDIXIC ACID.用萘啶酸治疗尿路感染
N Z Med J. 1964 Aug;63:498-501.
4
ABSORPTION, EXCRETION, AND METABOLISM OF A NEW ANTIBACTERIAL AGENT, NALIDIXIC ACID.新型抗菌剂萘啶酸的吸收、排泄及代谢
Toxicol Appl Pharmacol. 1964 May;6:292-309. doi: 10.1016/0041-008x(64)90070-5.
5
Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites.核酸衍生物拮抗剂。VIII. 生物化学相关抗代谢物组合中的协同作用。
J Biol Chem. 1954 Jun;208(2):477-88.
6
Nalidixic acid: clinical and laboratory studies.萘啶酸:临床与实验室研究。
Antimicrob Agents Chemother (Bethesda). 1966;6:189-97.
7
[Antibacterial activity in vitro of nalidixic acid-neomycin].
Antibiotica. 1968 Jun;6(2):72-80.
8
Pharmacokinetics of sulfamethoxazole plus trimethoprim in man and their distribution in the rat.磺胺甲恶唑加甲氧苄啶在人体中的药代动力学及其在大鼠体内的分布。
Chemotherapy. 1970;15(6):337-55. doi: 10.1159/000220701.
9
Trimethoprim, a sulphonamide potentiator.甲氧苄啶,一种磺胺增效剂。
Br J Pharmacol Chemother. 1968 May;33(1):72-90. doi: 10.1111/j.1476-5381.1968.tb00475.x.
10
Folate antagonists as antibacterial and antiprotozoal agents.作为抗菌和抗原生动物药物的叶酸拮抗剂。
Ann N Y Acad Sci. 1971 Nov 30;186:444-51. doi: 10.1111/j.1749-6632.1971.tb31171.x.