Reudelhuber T L, Boulikas T, Garrard W T
J Biol Chem. 1980 May 25;255(10):4511-5.
The results of dimethyl suberimidate cross-linking experiments demonstrate that histone H1 can be cross-linked quantitatively to the histone octamer of mononucleosomes to yield a histone nonamer. By combining our cross-linking procedure with two-dimensional electrophoretic techniques, we show further that it is possible to trace the nucleosomal origins of a spectrum of cross-linked chromatin products.
亚胺二甲酯交联实验结果表明，组蛋白H1可定量交联至单核小体的组蛋白八聚体上，从而产生组蛋白九聚体。通过将我们的交联程序与二维电泳技术相结合，我们进一步表明，追踪一系列交联染色质产物的核小体起源是可能的。
