甘露糖苷贮积症的尿寡糖
Urinary oligosaccharides of mannosidosis.
作者信息
Yamashita K, Tachibana Y, Mihara K, Okada S, Yabuuchi H, Kobata A
出版信息
J Biol Chem. 1980 Jun 10;255(11):5126-33.
PMID:7372628
Abstract
Nine oligosaccharide fractions were purified from the urine of mannosidosis patients by Bio-Gel P-4 column chromatography, paper chromatography, and paper electrophoresis. Studies using exoglycosidase digestion, methylation analysis, periodate oxidation, and acetolysis revealed that most of the fractions were mixtures of two or three isomeric oligosaccharides. The structures of a total of 16 oligosaccharides were elucidated to be as follows: (formula: see text).
摘要
通过Bio-Gel P-4柱色谱法、纸色谱法和纸电泳法从甘露糖苷贮积症患者的尿液中纯化出9种寡糖级分。使用外切糖苷酶消化、甲基化分析、高碘酸盐氧化和乙酰解的研究表明，大多数级分是两种或三种异构寡糖的混合物。总共16种寡糖的结构已阐明如下：（分子式：见正文）。
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