Holtermüller K H, Herzog P, Huhn B, Müller T, Naumann C, Castro M
Klin Wochenschr. 1980 Mar 17;58(6):307-12. doi: 10.1007/BF01476573.
The effects of varying loads of intraduodenal phenylalanine on pancreatic and gallbladder function were investigated in 32 healthy volunteers using a triple lumen perfusion system. L-phenylalanine absorption rates in the proximal jejunum were measured simultaneously. Intraduodenal L-phenylalanine produced a dose related increase in pancreatic secretion reaching the maximum at the concentration of 100 mM. Bilirubin outputs too increased significantly but did not parallel enzyme secretion. In contrast to the effect of L-phenylalanine, D-phenylalanine 50 mM did not stimulate pancreatic enzyme secretion and gallbladder emptying. The absorption rates of L-phenylalanine increased with rising luminal concentrations. There was a significant correlation between pancreatic secretion and L-phenylalanine absorption rates. This relationship suggests that the release of cholecystokinin, a hormone stimulating pancreatic and biliary function is dependant of the absorption of nutrients like amino acids.
利用三腔灌注系统，在32名健康志愿者中研究了十二指肠内不同负荷的苯丙氨酸对胰腺和胆囊功能的影响。同时测量了空肠近端L-苯丙氨酸的吸收率。十二指肠内L-苯丙氨酸使胰腺分泌呈剂量相关增加，在浓度为100 mM时达到最大值。胆红素输出也显著增加，但与酶分泌不平行。与L-苯丙氨酸的作用相反，50 mM的D-苯丙氨酸不刺激胰腺酶分泌和胆囊排空。L-苯丙氨酸的吸收率随管腔浓度升高而增加。胰腺分泌与L-苯丙氨酸吸收率之间存在显著相关性。这种关系表明，刺激胰腺和胆汁功能的激素胆囊收缩素的释放依赖于氨基酸等营养物质的吸收。
