Malagelada J R, Holtermuller K H, McCall J T, Go V L
Am J Dig Dis. 1978 Jun;23(6):481-5. doi: 10.1007/BF01072690.
To assess the effects of magnesium chloride or magnesium sulfate on the release of cholecystokinin from the duodenum, outputs of trypsin and bilirubin were quantified during perfusion of the duodenum with isotonic solutions of these salts. Net intestinal water transport was also quantified. The results suggest that magnesium ion in the duodenum is a relatively weak stimulus to the pancreas and gallbladder, an action not augmented by the concomitant presence of the sulfate ion. As determined by this human bioassay method, magnesium is a weak stimulant to cholecystokinin release. Furthermore, magnesium chloride inhibits net jejunal water absorption and magnesium sulfate is even more potent, promoting net water secretion, effects which cannot be entirely attributed to cholecystokinin release.
为评估氯化镁或硫酸镁对十二指肠中胆囊收缩素释放的影响，在用这些盐的等渗溶液灌注十二指肠期间，对胰蛋白酶和胆红素的输出量进行了定量测定。还对肠道净水转运进行了定量测定。结果表明，十二指肠中的镁离子对胰腺和胆囊是相对较弱的刺激物，硫酸根离子的同时存在不会增强这种作用。通过这种人体生物测定方法确定，镁是胆囊收缩素释放的弱刺激物。此外，氯化镁抑制空肠净水吸收，而硫酸镁的作用更强，可促进净水分泌，这些作用不能完全归因于胆囊收缩素的释放。
