Malagelada J R, DiMagno E P, Summerskill W H, Go V L
J Clin Invest. 1976 Aug;58(2):493-9. doi: 10.1172/JCI108493.
The effects of intraduodenal glycerol, fatty acid (FA) chain length and FA loads, and bile acid (BA) concentrations on pancreatic and gallbladder function were investigated in 31 healthy volunteers by a perfusion method. FA absorption rates in the duodenum and proximal jejunum were measured simultaneously. Pancreatic and gallbladder responses were augmented by increasing FA chain length and FA loads until the "maximal" secretory capacity of the pancreas and gallbladder emptying was attained. Glycerol had no effect. Raising BA concentrations above the critical micellar concentration accelerated FA absorption rates but decreased the magnitude of pancreatic and gallbladder responses to FA. Higher BA concentrations exerted an opposite effect, slowing FA absorption and increasing pancreatic and gallbladder responses. Indeed, a significant, inverse correlation was found between FA absorption and pancreatic and gallbladder responses to FA, suggesting a relationship between the length of intestine exposed to FA and the amount of cholecystokinin (and/or other neurohormonal factors) released, which stimulates pancreatic secretion and gallbladder contraction.
采用灌注法，在31名健康志愿者中研究十二指肠内甘油、脂肪酸（FA）链长度和FA负荷以及胆汁酸（BA）浓度对胰腺和胆囊功能的影响。同时测量十二指肠和空肠近端的FA吸收率。随着FA链长度和FA负荷增加，胰腺和胆囊反应增强，直至达到胰腺的“最大”分泌能力和胆囊排空。甘油无作用。将BA浓度提高到临界胶束浓度以上可加速FA吸收率，但会降低胰腺和胆囊对FA反应的幅度。更高的BA浓度则产生相反的作用，减缓FA吸收并增加胰腺和胆囊反应。实际上，在FA吸收与胰腺和胆囊对FA的反应之间发现了显著的负相关，这表明暴露于FA的肠段长度与释放的胆囊收缩素（和/或其他神经激素因子）量之间存在关联，后者会刺激胰腺分泌和胆囊收缩。
