Nervi A M, Peluffo R O, Brenner R R, Leikin A I
Lipids. 1980 Apr;15(4):263-8. doi: 10.1007/BF02535837.
The effect of ethanol on the fatty acid desaturation by rat liver has been studied using liquid diets of different composition. Acute ethanol administration increased triacylglycerols of total liver lipids, but did not modify significantly the lipidic composition of microsomes. The delta 6 and delta 5 desaturases were inhibited by ethanol whereas the delta 9 desaturase and fatty acid synthetase were apparently modified only by diet composition. NADH-cytochrome (cyt.) c reductase was partially inhibited, whereas NADH-cyt. b5 reductase remained practically unaltered and NADPH-cyt. c reductase activity was enhanced. Decreased electrons supplied by the microsomal cyt. b5 electron transport chain would not be the reason for the inhibition of delta 6 and delta 5 desaturases by ethanol.
使用不同成分的流质饮食，研究了乙醇对大鼠肝脏脂肪酸去饱和作用的影响。急性给予乙醇会增加肝脏总脂质中的三酰甘油含量，但对微粒体的脂质组成没有显著影响。乙醇会抑制δ6和δ5去饱和酶，而δ9去饱和酶和脂肪酸合成酶显然仅受饮食成分的影响。NADH-细胞色素（cyt.）c还原酶受到部分抑制，而NADH-cyt. b5还原酶基本保持不变，NADPH-cyt. c还原酶活性增强。微粒体细胞色素b5电子传递链提供的电子减少并非乙醇抑制δ6和δ5去饱和酶的原因。
