稳定的48Ca在肠道钙吸收临床测量中的应用。

Use of stable 48Ca in the clinical measurement of intestinal calcium absorption.

作者信息

Neer R, Tully G, Schatz P, Hnatowich D J

出版信息

Calcif Tissue Res. 1978 Nov 10;26(1):5-11. doi: 10.1007/BF02013226.

DOI:10.1007/BF02013226

Abstract

Measurements of intestinal-calcium-absorption efficiency are fundamental for understanding calcium homeostasis in health and disease. Stable calcium isotopes are attractive tracers for such measurements, to avoid excessive radiation exposure to the subject and permit serial studies at short intervals. To realize this, we found it necessary to improve the sensitivity and precision of existing thermal neutron activation analyses for 48Ca. This report describes the details, sensitivity, precision, and accuracy of the improved method, and gives the results of studies in which intravenous 48Ca was used in conjunction with oral 47Ca to measure intestinal-calcium-absorption efficiency in patients.

摘要

测量肠道钙吸收效率对于理解健康和疾病状态下的钙稳态至关重要。稳定钙同位素是进行此类测量的理想示踪剂，可避免受试者受到过多辐射暴露，并允许在短时间间隔内进行系列研究。为实现这一点，我们发现有必要提高现有用于48Ca热中子活化分析的灵敏度和精密度。本报告描述了改进方法的细节、灵敏度、精密度和准确性，并给出了在患者中使用静脉注射48Ca结合口服47Ca来测量肠道钙吸收效率的研究结果。