人体血液中自然杀伤细胞和杀伤细胞活性：依性别、年龄和疾病的差异
NK and K cell activity of human blood: differences according to sex, age, and disease.
作者信息
Penschow J, Mackay I R
出版信息
Ann Rheum Dis. 1980 Feb;39(1):82-6. doi: 10.1136/ard.39.1.82.
Abstract
We report a study on the activity of NK cells ('natural' killer cells) and K cells (antibody-dependent killer cells) in human peripheral blood in health and disease. The 'targets' used were cells of the Chang cell-line, sensitised with rabbit anti-Chang cell antibody for K cell activity, and killing was assessed by release of radiochromium at effector: target ratios of 50:1 and 100:1. The positive findings were that NK cell activity, but not K cell activity, was greater in males and in youth, that NK cell activity was reduced in systemic lupus erythematosus, that neither NK nor K cell activity was altered in rheumatoid arthritis, and that K cell activity was reduced in chronic active hepatitis.
摘要
我们报告了一项关于健康和疾病状态下人体外周血中自然杀伤细胞（NK细胞）和杀伤细胞（K细胞，抗体依赖性杀伤细胞）活性的研究。所用的“靶细胞”是Chang细胞系的细胞，用兔抗Chang细胞抗体致敏以检测K细胞活性，通过在效应细胞与靶细胞比例为50:1和100:1时放射性铬的释放来评估杀伤情况。阳性结果为：男性和年轻人的NK细胞活性较高，而K细胞活性无此差异；系统性红斑狼疮患者的NK细胞活性降低；类风湿性关节炎患者的NK细胞和K细胞活性均无改变；慢性活动性肝炎患者的K细胞活性降低。
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