抗凝血酶III参与硫酸纤维素抗凝活性的证据。
Evidence for antithrombin III involvement in the anticoagulant activity of cellulose sulphate.
作者信息
Kindness G, Long W F, Williamson F B
出版信息
Br J Pharmacol. 1980 Apr;68(4):645-9. doi: 10.1111/j.1476-5381.1980.tb10856.x.
Abstract
1 Cellulose sulphate, like heparin, prolonged the clotting time in partial thromboplastin time (PTT) assays, inhibited the amidolytic activity of thrombin, was without effect on amidolysis catalysed by activated coagulation factor X(Xa), and potentiated the inhibition of both thrombin and Xa by antithrombin III (AT). 2 The anticoagulant activity of cellulose sulphate in PTT assays was, like that of heparin and heparin sulphate, but unlike that of dermatan sulphate, reduced by prior incubation of plasma with antiserum specific for AT. 3 These results, which suggest that the anticoagulant activity of cellulose sulphate is at least partially mediated through AT, are discussed in terms of the structural features of polysaccharides required for AT activation.
摘要
- 硫酸纤维素与肝素一样，在部分凝血活酶时间（PTT）测定中延长凝血时间，抑制凝血酶的酰胺水解活性，对活化凝血因子X（Xa）催化的酰胺水解无影响，并增强抗凝血酶III（AT）对凝血酶和Xa的抑制作用。2. 在PTT测定中，硫酸纤维素的抗凝活性与肝素和硫酸肝素的抗凝活性一样，但与硫酸皮肤素不同，血浆与AT特异性抗血清预先孵育后，其抗凝活性降低。3. 这些结果表明硫酸纤维素的抗凝活性至少部分是通过AT介导的，本文根据AT激活所需多糖的结构特征对这些结果进行了讨论。
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Effect of sulphated polysaccharides on the alpha 1-antitrypsin inhibition of amidolysis catalysed by coagulation cascade proteinases.硫酸化多糖对凝血级联蛋白酶催化的酰胺水解中α1-抗胰蛋白酶抑制作用的影响。
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