硫酸纤维素在正常大鼠和肾上腺切除大鼠血浆中诱发的纤溶活性。

Fibrinolytic activity evoked in the plasma of the normal and adrenalectomized rat by cellulose sulphate.

Rosa A T, Rothschild A M, Rothschild Z

Br J Pharmacol. 1972 Jul;45(3):470-5. doi: 10.1111/j.1476-5381.1972.tb08103.x.

Abstract

Cellulose sulphate, a kinin-releasing agent, produced fibrinolytic activity in plasma when administered intravenously to the rat but not when added to fresh rat plasma in vitro. The in vivo effect was maximal within 1 min and disappeared within 10-20 minutes. It was retained in plasma taken 1 min after the injection and kept at room temperature for 30 minutes.2. A decrease of anti-fibrinolytic potency measured against urokinase-activated bovine plasmin, was shown to occur in plasma of rats given cellulose sulphate.3. Activated rat plasma lysed heat-denatured fibrin: it probably contains free plasmin as well as plasminogen activator.4. Adrenalectomized rats did not exhibit fibrinolytic activity nor statistically significant benzoyl-arginine ethyl ester-esterase activation in plasma after cellulose sulphate treatment.5. Adrenalectomized rats had significantly increased levels of plasma kininogen, but were normally sensitive to the kininogen-depleting action of cellulose sulphate.6. The increased plasma kininogen of adrenalectomized rats seems to be a consequence of the impairment of the plasminogen activating mechanism.

摘要

硫酸纤维素是一种激肽释放剂，静脉注射给大鼠时可在血浆中产生纤溶活性，但体外添加到新鲜大鼠血浆中时则不会。体内效应在1分钟内达到最大，并在10 - 20分钟内消失。它在注射后1分钟采集的血浆中保留，并在室温下保存30分钟。
对用硫酸纤维素处理的大鼠血浆进行检测，发现其针对尿激酶激活的牛纤溶酶的抗纤溶能力有所下降。
激活的大鼠血浆可溶解热变性纤维蛋白：它可能既含有游离纤溶酶，也含有纤溶酶原激活剂。
肾上腺切除的大鼠在硫酸纤维素处理后，血浆中未表现出纤溶活性，也未出现统计学上显著的苯甲酰精氨酸乙酯酯酶激活。
肾上腺切除的大鼠血浆激肽原水平显著升高，但对硫酸纤维素的激肽原消耗作用正常敏感。
肾上腺切除的大鼠血浆激肽原增加似乎是纤溶酶原激活机制受损的结果。