Silberman E K, Vivaldi E, Garfield J, McCarley R W, Hobson J A
Brain Res. 1980 Jun 2;191(1):215-24. doi: 10.1016/0006-8993(80)90324-8.
Two physical factors affecting the behavioral effects of drugs microinjected into the pontine tegmentum have been studied. Reducing the volume of vehicle produced a dramatic enhancement of the capacity of the long-acting cholinergic agent carbachol to induce desynchronized (D) sleep-like behavior (Dcarb). Enhancement of Dcarb was also achieved by substitute passive diffusion for active pumping of a given volume of carbachol solution. Controlling these two physical factors makes Dcarb a compelling experimental model for the study of D sleep mechanisms. The results also give support to the concept of a localized population of cholinoceptive neurons in the pontine reticular formation whose activation is a key step in the generation of physiological D.
已经研究了影响微量注射到脑桥被盖中的药物行为效应的两个物理因素。减少溶媒体积会显著增强长效胆碱能药物卡巴胆碱诱导去同步化（D）睡眠样行为（Dcarb）的能力。通过用被动扩散替代给定体积卡巴胆碱溶液的主动泵注，也能增强Dcarb。控制这两个物理因素使Dcarb成为研究D睡眠机制的一个有说服力的实验模型。这些结果也支持了脑桥网状结构中存在局部胆碱能感受神经元群体的概念，其激活是生理性D产生的关键步骤。
