活动期白塞病中的循环免疫复合物
Circulating immune complexes in active Behçet's disease.
作者信息
Gupta R C, O'Duffy J D, McDuffie F C, Meurer M, Jordon R E
出版信息
Clin Exp Immunol. 1978 Nov;34(2):213-8.
Levels of immune complexes (IC) were determined by the Raji-cell and C1q-binding radioimmunoassays in the sera of eighteen patients with Behçet's disease. Eight patients (44%) were found to have significantly elevated levels of IC (range 56 to 1600 microgram equivalent aliquots of heat aggregated IgG (AHG/ml) by the former test and nine by the latter (7 to 500 microgram equivalent AHG/ml). The presence of IC showed a significant correlation with disease activity score (P = 0.003, Mann-Whitney Rank Sum Test). Abnormal values of IC tended to remain abnormal when sera were retested after 1 year. There was no correlation between IC and duration of disease or any specific organ involvement. The IC were found predominantly in fractions of about 19S and greater when fractionated by sucrose density gradient or Sephadex column techniques. The results suggest the possibility that IC may contribute to the pathophysiology of Behçet's disease.
采用Raji细胞法和C1q结合放射免疫分析法检测了18例白塞病患者血清中的免疫复合物（IC）水平。结果发现，8例患者（44%）的IC水平显著升高（前一种检测方法中，IC水平范围为56至1600微克当量热聚集IgG（AHG/ml），后一种检测方法中有9例患者升高（7至500微克当量AHG/ml）。IC的存在与疾病活动评分显著相关（P = 0.003，曼-惠特尼秩和检验）。1年后重新检测血清时，IC的异常值往往仍保持异常。IC与疾病持续时间或任何特定器官受累情况之间无相关性。通过蔗糖密度梯度或葡聚糖凝胶柱技术进行分离时，IC主要存在于约19S及更大的组分中。这些结果提示IC可能参与了白塞病的病理生理过程。
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