Cooper R, Soltero I, Liu K, Berkson D, Levinson S, Stamler J
Circulation. 1980 Jul;62(1):97-104. doi: 10.1161/01.cir.62.1.97.
This study explored the association between sodium excretion and blood pressure (BP). A new method was used to minimize the measurement error introduced by the large intrinsic variability of 24-hour sodium excretion. The ratio of intra- to interindividual variation was used to estimate the number of measurements needed to characterize the individual. When seven consecutive 24-hour samples were collected from 73 children, ages 11-14 years, a significant correlation between mean individual sodium excretion and BP was demonstrated. The independent relationship persisted when controlling for height, weight, pulse, age, sex and race (p = 0.045), but was eliminated by simultaneously considering mean creatinine excretion. Although the cross-sectional association described is quantitatively weak, a linear relationship between BP and sodium over the range consumed in this society could be important for prevention.
本研究探讨了钠排泄与血压（BP）之间的关联。采用了一种新方法，以尽量减少24小时钠排泄量的巨大内在变异性所引入的测量误差。个体内变异与个体间变异的比率用于估计表征个体所需的测量次数。当从73名11至14岁的儿童中连续收集七个24小时样本时，个体平均钠排泄量与血压之间显示出显著相关性。在控制身高、体重、脉搏、年龄、性别和种族后，这种独立关系依然存在（p = 0.045），但在同时考虑平均肌酐排泄量时这种关系消失了。尽管所描述的横断面关联在数量上较弱，但在这个社会所摄入的范围内，血压与钠之间的线性关系可能对预防具有重要意义。
