Mee A S, Nuttall L, Potter B J, Jewell D P
Clin Exp Immunol. 1980 Mar;39(3):785-91.
The effect of endotoxin and immune complexes on monocyte lysosomal enzyme activity has been studied in patients with Crohn's disease and ulcerative colitis. Immune complexes made at equivalence or in antigen excess caused a rapid fall in intracellular activity of the enzyme N'acetyl-beta-D-glucosaminidase which was significantly greater than that seen when cells were incubated with medium alone. Endotoxin had no effect on intracellular enzyme activity but there was a significant elevation of activity in the supernatants. Cells from patients with inflammatory bowel disease were no different to cells from healthy control subjects in their response to either endotoxin or immune complexes.
在内毒素和免疫复合物对单核细胞溶酶体酶活性的影响方面，已经对克罗恩病和溃疡性结肠炎患者进行了研究。等当量或抗原过量情况下形成的免疫复合物会导致N-乙酰-β-D-氨基葡萄糖苷酶的细胞内活性迅速下降，这一下降幅度显著大于细胞仅与培养基孵育时的情况。内毒素对细胞内酶活性没有影响，但上清液中的活性有显著升高。炎症性肠病患者的细胞与健康对照受试者的细胞对内毒素或免疫复合物的反应没有差异。
