微管蛋白是否参与离体大鼠坐骨神经的电诱导机械活性？
Is tubulin involved in the electrically-induced mechanical activity of the isolated rat sciatic nerve?
作者信息
Valenti C E, de Gimeno M F, Cardinali D P, Gimeno A L
出版信息
Experientia. 1980 Apr 15;36(4):425-7. doi: 10.1007/BF01975126.
PMID:7379913
Abstract
The electrically-induced mechanical activity of isolated segments of rat sciatic nerves remains unaffected following incubation with 10(-4) M colchicine, vinblastine or melatonin. Vinblastine depressed tubulin levels in incubated nerves. These results suggest that microtubules are not involved in nerve mechanical activity in vitro.
摘要
用10⁻⁴M秋水仙碱、长春碱或褪黑素孵育后，大鼠坐骨神经离体节段的电诱导机械活性未受影响。长春碱降低了孵育神经中的微管蛋白水平。这些结果表明，微管在体外神经机械活性中不发挥作用。
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