大鼠坐骨神经中的快速轴突运输。松果体吲哚的抑制作用。

Fast axonal transport in rat sciatic nerve. Inhibition by pineal indoles.

作者信息

Prevedello M R, Ritta M N, Cardinali D P

出版信息

Neurosci Lett. 1979 Jun;13(1):29-34. doi: 10.1016/0304-3940(79)90070-3.

Abstract

The effect of pineal indoles on fast axoplasmic transport of proteins in the sciatic nerve was examined in rats injected with [3H]leucine in the sixth lumbar dorsal root ganglion. Melatonin (350-1100 nmol) applied locally in the sciatic nerve impaired significantly axonal transport. At a 350-nmol dose all other indoles tested (i.e., 5-hydroxyindoleacetic acid, 5-methoxyindoleacetic acid, serotonin, N-acetylserotonin, tryptamine, 5-methoxytryptamine) were less potent than melatonin to impair fast axonal flow. Vinblastine injected either into the ganglion or in the sciatic nerve markedly inhibited axonal transport.

摘要

在第六腰段背根神经节注射[3H]亮氨酸的大鼠中，研究了松果体吲哚对坐骨神经中蛋白质快速轴浆运输的影响。局部应用于坐骨神经的褪黑素（350 - 1100纳摩尔）显著损害轴突运输。在350纳摩尔剂量下，所有其他测试的吲哚（即5 - 羟吲哚乙酸、5 - 甲氧基吲哚乙酸、血清素、N - 乙酰血清素、色胺、5 - 甲氧基色胺）损害快速轴突流动的效力均低于褪黑素。注射到神经节或坐骨神经中的长春花碱显著抑制轴突运输。