Sawka M N, Young A J, Muza S R, Gonzalez R R, Pandolf K B
JAMA. 1987 Mar 20;257(11):1496-9.
Induced erythrocythemia is associated with a variable increase in maximal oxygen uptake. To examine the roles of the magnitude of change in hemoglobin concentration and the individual's initial aerobic fitness in this effect, we combined individual data from our own research and three other studies. In each study freeze-preserved erythrocytes from the product of 2 units of blood were reinfused, and maximal oxygen uptake was measured within 24 to 72 hours after reinfusion. The 30 subjects had an initial aerobic power of 36 to 88 mL of oxygen per kilogram per minute. The combined results from these studies indicate that after erythrocyte reinfusion the increase in hemoglobin concentration is fairly homogeneous (mean +/- SD, 1.36 +/- 0.6 g/dL [13.6 +/- 6 g/L]), nearly all individuals demonstrate an increase in maximal oxygen uptake (0.357 +/- 0.216 L/min), the magnitude of increase in hemoglobin concentration is not related to the magnitude of increase in maximal oxygen uptake, and the magnitude of increase in maximal oxygen uptake is related to the individual's initial aerobic fitness. Individuals with an initial aerobic fitness between 50 and 65 mL X kg-1 X min-1 experience approximately twice the increase in maximal oxygen uptake after erythrocyte reinfusion of individuals with greater fitness and also of lesser fitness.
诱导性红细胞增多症与最大摄氧量的不同程度增加相关。为了研究血红蛋白浓度变化幅度和个体初始有氧适能在此效应中的作用，我们整合了来自我们自己的研究以及其他三项研究的个体数据。在每项研究中，将来自2单位血液制品的冷冻保存红细胞回输，并在回输后24至72小时内测量最大摄氧量。这30名受试者的初始有氧能力为每分钟每千克36至88毫升氧气。这些研究的综合结果表明，红细胞回输后血红蛋白浓度的增加相当均匀（平均值±标准差，1.36±0.6克/分升[13.6±6克/升]），几乎所有个体的最大摄氧量都有所增加（0.357±0.216升/分钟），血红蛋白浓度的增加幅度与最大摄氧量的增加幅度无关，而最大摄氧量的增加幅度与个体的初始有氧适能有关。初始有氧适能在50至65毫升×千克⁻¹×分钟⁻¹之间的个体，红细胞回输后最大摄氧量的增加幅度约为有氧适能较高和较低个体的两倍。
