Thomson J M, Stone J A, Ginsburg A D, Hamilton P
J Appl Physiol Respir Environ Exerc Physiol. 1982 Nov;53(5):1213-9. doi: 10.1152/jappl.1982.53.5.1213.
Reasons for an increase in maximal O2 consumption (VO2max) following blood reinfusion remain unclear; thus the present investigation was undertaken to examine the arterial and femoral venous blood gases during submaximal and maximal exercise. Four untrained males (22-25 yr) performed modified Balke work capacity tests under control conditions (Hct = 42.4 +/- 0.8%; Hb = 14.7 +/- 0.5 g X 100 ml-1) and following autologous blood reinfusion (Hct = 46.2 +/- 1.3%; Hb = 16.4 +/- 0.9 g X 100 ml-1). VO2 was determined by open-circuit spirometry and cardiac output by the N2O method; radial arterial and deep femoral venous blood were sampled at each work load throughout the incremental work tests. Following blood reinfusion, subjects' VO2max increased (P less than 0.05) from 4.0 (in control) to 4.5 1 X min-1. Throughout submaximal exercise arterial PO2 remained relatively constant (between 80.1 +/- 4.4 and 89.1 +/- 5.0 Torr) and cardiac output unchanged, comparing the two experimental conditions. Femoral venous PO2 values were almost identical throughout the work capacity tests, declining at exhaustion to 15.7 +/- 1.5 Torr in control and to 13.8 +/- 3.3 Torr postreinfusion. It appeared that the subjects' increase in VO2max postreinfusion was due to an increased O2 supplied to the tissue [i.e., cardiac output (Q) X arterial O2 content (CaO2)] by the central circulation. This resulted from a small (10%) increase in Q and a constant elevation in CaO2 of 1.7-2.2 ml X 100 ml-1, since virtually no changes were observed in the femoral venous blood postreinfusion and the acid-base status and temperature, important determinant of O2 dissociation, were (almost) identical, comparing the two experimental conditions.
输血后最大摄氧量（VO2max）增加的原因尚不清楚；因此，本研究旨在检测次最大和最大运动期间的动脉血和股静脉血气。四名未经训练的男性（22 - 25岁）在对照条件下（血细胞比容 = 42.4 ± 0.8%；血红蛋白 = 14.7 ± 0.5 g×100 ml-1）以及自体输血后（血细胞比容 = 46.2 ± 1.3%；血红蛋白 = 16.4 ± 0.9 g×100 ml-1）进行改良的Balke运动能力测试。VO2通过开路肺量计测定，心输出量通过氧化亚氮法测定；在递增运动测试的每个工作负荷下采集桡动脉和股深静脉血样。输血后，受试者的VO2max从对照时的4.0增加到4.5 l×min-1（P < 0.05）。在整个次最大运动期间，比较两种实验条件，动脉血氧分压（PO2）保持相对恒定（在80.1 ± 4.4和89.1 ± 5.0 Torr之间），心输出量不变。在整个运动能力测试中，股静脉PO2值几乎相同，在疲劳时对照下降至15.7 ± 1.5 Torr，输血后下降至13.8 ± 3.3 Torr。似乎输血后受试者VO2max的增加是由于中央循环向组织供应的氧气增加[即心输出量（Q）×动脉血氧含量（CaO2）]。这是由于Q小幅增加（10%）以及CaO2持续升高1.7 - 2.2 ml×100 ml-1，因为输血后股静脉血几乎没有变化，并且比较两种实验条件，作为氧气解离重要决定因素的酸碱状态和温度（几乎）相同。
