费伦西霉素A和B。两种聚醚类抗生素。分类学、发酵、分离、表征及结构研究。

Ferensimycins A and B. Two polyether antibiotics. Taxonomy, fermentation, isolation, characterization and structural studies.

作者信息

Kusakabe Y, Mizuno T, Kawabata S, Tanji S, Seino A, Seto H, Otake N

出版信息

J Antibiot (Tokyo). 1982 Sep;35(9):1119-29. doi: 10.7164/antibiotics.35.1119.

DOI:10.7164/antibiotics.35.1119

PMID:7142018

Abstract

Ferensimycin A* (I), C34H59O10Na, mp 133 approximately 135 degrees C, and ferensimycin B** (II), C35H61O10Na, mp 143 approximately 145 degrees C, were isolated as their sodium salts from the fermentation broth of Streptomyces sp. No. 5057, a strain similar to Streptomyces myxogenes Shomura et al. The physicochemical data of I and II showed that they are both closely related congeners of lysocellin (III). Ferensimycins A and B exhibit activity against Gram-positive bacteria and are effective in the treatment of coccidiosis of fowl.

摘要

费伦西霉素A*（I），C34H59O10Na，熔点133至135摄氏度，以及费伦西霉素B**（II），C35H61O10Na，熔点143至145摄氏度，从链霉菌属5057号菌株的发酵液中分离得到其钠盐，该菌株与产黏液链霉菌Shomura等人的菌株相似。I和II的物理化学数据表明它们都是溶胞菌素（III）的紧密相关同系物。费伦西霉素A和B对革兰氏阳性菌具有活性，并且在治疗家禽球虫病方面有效。