Shoji J, Sakazaki R, Wakisaka Y, Koizumi K, Matsuura S, Miwa H, Mayama M
J Antibiot (Tokyo). 1980 Feb;33(2):182-5. doi: 10.7164/antibiotics.33.182.
A new peptide antibiotic complex, named octapeptin D, was isolated from culture broth of a microorganism belonging to the genus Bacillus. The trihydrochloride of the antibiotic was obtained as a colorless powder, soluble in water and methanol. The empirical formula, C47H88N12O11.3HCl.H2O, was indicated by elemental analysis. Amino acid analysis on the acid hydrolyzate demonstrated the presence of 2,4-diaminobutyric acid (4 moles), serine (1 mole) and leucine (3 moles). Gas chromatographic analysis with the methylated product of the ethereal extract of the acid hydrolyzate revealed the presence of beta-hydroxy isodecanoic acid, beta-hydroxy decanoic acid, beta-hydroxy isoundecanoic acid and beta-hydroxyanteisoundecanoic acid. Octapeptin D is active against Gram-negative and Gram-positive bacteria in vitro and in vivo.
一种名为八肽菌素D的新型肽类抗生素复合物，是从芽孢杆菌属的一种微生物的培养液中分离出来的。该抗生素的三盐酸盐为无色粉末，可溶于水和甲醇。元素分析表明其经验式为C47H88N12O11.3HCl.H2O。对酸水解产物的氨基酸分析表明存在2,4-二氨基丁酸（4摩尔）、丝氨酸（1摩尔）和亮氨酸（3摩尔）。对酸水解产物的乙醚提取物的甲基化产物进行气相色谱分析，发现存在β-羟基异癸酸、β-羟基癸酸、β-羟基异十一烷酸和β-羟基反异十一烷酸。八肽菌素D在体外和体内对革兰氏阴性菌和革兰氏阳性菌均有活性。
