短小菌素，一种新型抗病毒抗生素复合物。生产、分离、化学性质、结构及生物活性。
Pumilacidin, a complex of new antiviral antibiotics. Production, isolation, chemical properties, structure and biological activity.
作者信息
Naruse N, Tenmyo O, Kobaru S, Kamei H, Miyaki T, Konishi M, Oki T
机构信息
Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.
出版信息
J Antibiot (Tokyo). 1990 Mar;43(3):267-80. doi: 10.7164/antibiotics.43.267.
New antibiotic pumilacidins A, B, C, D, E, F and G were isolated from the culture broth of a strain of Bacillus pumilus. They are cyclic acylheptapeptide composed of a beta-hydroxy fatty acid, two L-leucine, two D-leucine, L-glutamic acid, L-aspartic acid and L-isoleucine (or L-valine). Pumilacidin components were inhibitory to herpes simplex virus type 1 and H+, K(+)-ATPase and demonstrated antiulcer activity in rat.
新型抗生素短小杆菌肽A、B、C、D、E、F和G是从短小芽孢杆菌菌株的培养液中分离得到的。它们是由β-羟基脂肪酸、两个L-亮氨酸、两个D-亮氨酸、L-谷氨酸、L-天冬氨酸和L-异亮氨酸（或L-缬氨酸）组成的环状酰基七肽。短小杆菌肽成分对1型单纯疱疹病毒和H⁺、K⁺-ATP酶具有抑制作用，并在大鼠中表现出抗溃疡活性。
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