新型肽类抗生素短杆菌素的分离。芽孢杆菌属抗生素研究。IX。

Isolation of brevistin, a new peptide antibiotic. Studies on antibiotics from the genus Bacillus. IX.

作者信息

Shoji J, Sakazaki R, Wakisaka Y, Koizumi K, Mayama M

出版信息

J Antibiot (Tokyo). 1976 Apr;29(4):375-9. doi: 10.7164/antibiotics.29.375.

DOI:10.7164/antibiotics.29.375

Abstract

A new peptide antibiotic, brevistin, was isolated from the culture broth of Bacillus brevis 342-14. Brevistin is an acylpeptide with an approximate empirical formula of C63H91N15O18 containing aspartic acid, threonine, glycine, valine, isoleucine, phenylalanine, tryptophan and 2,4-diaminobutyric acid. The antibiotic is soluble in acid and alkaline water. Its hydrochloride is soluble in methanol. Brevistin is active against Ggam-positive bacteria in vitro and in vivo, and is of low toxicity to mice.

摘要

一种新的肽抗生素——短杆菌素，是从短短芽孢杆菌342 - 14的培养液中分离出来的。短杆菌素是一种酰基肽，其近似实验式为C63H91N15O18，含有天冬氨酸、苏氨酸、甘氨酸、缬氨酸、异亮氨酸、苯丙氨酸、色氨酸和2,4 - 二氨基丁酸。该抗生素可溶于酸性和碱性水。其盐酸盐可溶于甲醇。短杆菌素在体外和体内对革兰氏阳性菌均有活性，且对小鼠毒性较低。