BN - 183B，一种由假单胞菌产生的新型抗肿瘤抗生素。分类学、分离方法、理化性质及生物学特性

BN-183B, a new antitumor antibiotic produced by Pseudomonas. Taxonomy, isolation, physico-chemical and biological properties.

作者信息

Ezaki N, Miyadoh S, Hisamatsu T, Kasai T, Yamada Y

出版信息

J Antibiot (Tokyo). 1980 Feb;33(2):213-20. doi: 10.7164/antibiotics.33.213.

DOI:10.7164/antibiotics.33.213

Abstract

BN-183B is a new antitumor antibiotic with chlorine in its molecule found in the culture broth of Pseudomonas sp. BN-183. The compound was weakly basic and isolated as a hydrochloride in a pure state. The molecular formula of its free base was determined as C14H20N2O6Cl2. The antibiotic showed not only strong antimicrobial activity against both Gram-positive and Gram-negative bacteria but also marked activity toward experimental tumors such as lymphoid leukemia L-1210 and lymphocytic leukemia P-388 in mice. No mutagenicity of BN-183B was noted.

摘要

BN - 183B是一种在假单胞菌属BN - 183的培养液中发现的分子中含有氯的新型抗肿瘤抗生素。该化合物呈弱碱性，以盐酸盐形式被分离提纯。其游离碱的分子式确定为C14H20N2O6Cl2。这种抗生素不仅对革兰氏阳性菌和革兰氏阴性菌均表现出强大的抗菌活性，而且对小鼠的实验性肿瘤如淋巴白血病L - 1210和淋巴细胞白血病P - 388也有显著活性。未发现BN - 183B有诱变作用。