将IgM复合物结合至淋巴细胞和巨噬细胞所需的不同二价阳离子
Different divalent cation requirements for binding IgM complexes to lymphocytes and macrophages.
作者信息
Walia A S, Shaw D R, Fuson E W, Andersson B, Lamon E W
出版信息
J Exp Med. 1980 Jun 1;151(6):1528-33. doi: 10.1084/jem.151.6.1528.
Abstract
We have found that Mg++ supports IgM complex binding to mouse lymphocytes but not to macrophages. In contrast, Ca++ supports IgM complex binding to macrophages but not lymphocytes. IgG complex binding to both lymphocytes and macrophages is divalent cation independent. These findings allow one to distinguish IgG from IgM binding and macrophage from lymphocyte IgM complex binding by their differential divalent cation requirements.
摘要
我们发现，Mg++支持IgM复合物与小鼠淋巴细胞结合，但不支持与巨噬细胞结合。相比之下，Ca++支持IgM复合物与巨噬细胞结合，但不支持与淋巴细胞结合。IgG复合物与淋巴细胞和巨噬细胞的结合均不依赖二价阳离子。这些发现使人们能够根据它们对二价阳离子的不同需求来区分IgG与IgM的结合，以及巨噬细胞与淋巴细胞IgM复合物的结合。
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