人类淋巴细胞上的IgM受体：通过直接结合进行检测
IgM receptors on human lymphocytes: detection by direct binding.
作者信息
Hardin J A, Nakaoka K K, Carboni J M
出版信息
Proc Natl Acad Sci U S A. 1979 Feb;76(2):912-4. doi: 10.1073/pnas.76.2.912.
Abstract
Radioiodinated IgM isolated from a patient with Waldenström macroglobulinemia binds with high avidity (apparent Ka = 2.5 x 10(9) M-1) to freshly isolated human peripheral blood lymphocytes. Binding occurred through the Fc region of the molecule and involved a receptor specific for immunoglobulins of the IgM class. The avidity and specificity of this binding are consistent with a biologic role for IgM receptors on lymphocytes.
摘要
从一名华氏巨球蛋白血症患者体内分离出的放射性碘化IgM，能以高亲和力（表观解离常数Ka = 2.5 x 10⁹ M⁻¹）与新鲜分离的人外周血淋巴细胞结合。这种结合是通过该分子的Fc区域发生的，并且涉及一种对IgM类免疫球蛋白具有特异性的受体。这种结合的亲和力和特异性与淋巴细胞上IgM受体的生物学作用是一致的。
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J Clin Invest. 1960 Dec;39(12):1933-41. doi: 10.1172/JCI104218.
2
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Proc Natl Acad Sci U S A. 1970 Feb;65(2):318-22. doi: 10.1073/pnas.65.2.318.
3
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J Mol Biol. 1973 Sep 15;79(2):237-48. doi: 10.1016/0022-2836(73)90003-x.
4
Tissue factor activity in lymphocyte cultures from normal individuals and patients with hemophilia A.正常个体及甲型血友病患者淋巴细胞培养物中的组织因子活性。
J Clin Invest. 1973 Jun;52(6):1427-34. doi: 10.1172/JCI107316.
5
An enzymic method for the trace iodination of immunoglobulins and other proteins.一种用于免疫球蛋白及其他蛋白质微量碘化的酶法。
Biochem J. 1969 Jun;113(2):299-305. doi: 10.1042/bj1130299.
6
7
Binding of monomeric immunoglobulins to Fc receptors of mouse macrophages.单体免疫球蛋白与小鼠巨噬细胞Fc受体的结合。
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