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来自波希米亚酸复合物的抗肿瘤剂，III。马塞洛霉素、穆塞他霉素、鲁道夫霉素、米米霉素、科利内霉素、阿尔辛多霉素和波希米亚胺的分离。

Antitumor agents from bohemic acid complex, III. The isolation of marcellomycin, musettamycin, rudolphomycin, mimimycin, collinemycin, alcindoromycin, and bohemamine.

作者信息

Nettleton D E, Balitz D M, Doyle T W, Bradner W T, Johnson D L, O'Herron F A, Schreiber R H, Coon A B, Moseley J E, Myllymaki R W

出版信息

J Nat Prod. 1980 Mar-Apr;43(2):242-58. doi: 10.1021/np50008a003.

DOI:10.1021/np50008a003
PMID:7381507
Abstract

Six anthracycline antitumor agents, marcellomycin, musettamycin, rudolphomycin, alcindoromycin, collinemycin, and mimimycin, have now been isolated from bohemic acid complex. This has been achieved by classical column chromatography with Sephadex LH-20 and ammonia-neutralized silica and by analytical and prepatative hplc techniques with normal phase systems containing aqueous ammonia.

摘要

现已从波希米亚酸复合物中分离出六种蒽环类抗肿瘤药物，即马塞洛霉素、穆塞他霉素、鲁道夫霉素、阿尔辛多霉素、科利内霉素和米米霉素。这是通过使用葡聚糖凝胶LH - 20和氨中和硅胶的经典柱色谱法，以及采用含氨水的正相系统的分析型和制备型高效液相色谱技术实现的。

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