Catalona W J, Kadmon D, Crane D B
J Urol. 1980 Jun;123(6):890-2. doi: 10.1016/s0022-5347(17)56180-7.
To evaluate the effect of mini-dose heparin therapy on lymphocele formation after extraperitoneal pelvic lymphadenectomy we reviewed the records of 38 patients undergoing this procedure for prostatic cancer during a 24-month period. All patients had a minimum of 6 months of followup. Lymphoceles occurred in 3 of 8 patients (38 per cent) receiving mini-dose heparin and prolonged lymph drainage occurred in 1 other patient (12 per cent). In contrast, only 1 of 30 patients (3 per cent) not receiving mini-dose heparin had a lymphocele and 1 (3 per cent) had prolonged lymph drainage. The results suggest that mini-dose heparin may delay clotting of lymph and, thus, may be associated with an increased incidence of lymphocele formation after extraperitoneal lymphadenectomy.
为评估小剂量肝素治疗对腹膜外盆腔淋巴结清扫术后淋巴囊肿形成的影响，我们回顾了在24个月期间接受该手术治疗前列腺癌的38例患者的记录。所有患者至少随访6个月。接受小剂量肝素治疗的8例患者中有3例（38%）发生淋巴囊肿，另有1例患者（12%）出现淋巴引流延长。相比之下，未接受小剂量肝素治疗的30例患者中只有1例（3%）发生淋巴囊肿，1例（3%）出现淋巴引流延长。结果表明，小剂量肝素可能会延迟淋巴凝固，因此可能与腹膜外淋巴结清扫术后淋巴囊肿形成的发生率增加有关。
