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衰老、自然死亡与发病期的压缩。

Aging, natural death, and the compression of morbidity.

作者信息

Fries J F

出版信息

N Engl J Med. 1980 Jul 17;303(3):130-5. doi: 10.1056/NEJM198007173030304.

Abstract

The average length of life has risen from 47 to 73 years in this century, but the maximum life span has not increased. Therefore, survival curves have assumed an ever more rectangular form. Eighty per cent of the years of life lost to nontraumatic, premature death have been eliminated, and most premature deaths are now due to the chronic diseases of the later years. Present data allow calculation of the ideal average life span, approximately 85 years. Chronic illness may presumably be postponed by changes in life style, and it has been shown that the physiologic and psychologic markers of aging may be modified. Thus, the average age at first infirmity can be raised, thereby making the morbidity curve more rectangular. Extension of adult vigor far into a fixed life span compresses the period of senescence near the end of life. Health-research strategies to improve the quality of life require careful study of the variability of the phenomena of aging and how they may be modified.

摘要

本世纪人均寿命已从47岁增至73岁,但最长寿命并未增加。因此,生存曲线呈现出越来越接近矩形的形态。因非创伤性过早死亡而损失的寿命年数中,80%已被消除,现在大多数过早死亡是由晚年的慢性疾病导致的。目前的数据能够计算出理想的平均寿命,约为85岁。慢性病大概可以通过生活方式的改变而推迟发生,并且已经表明衰老的生理和心理指标是可以改变的。因此,可以提高首次出现身体衰弱的平均年龄,从而使发病曲线更接近矩形。在固定的寿命期限内将成年人的活力延长,会压缩生命末期的衰老阶段。改善生活质量的健康研究策略需要仔细研究衰老现象的变异性以及如何对其进行改变。

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