Dawling S, Crome P, Braithwaite R
Eur J Clin Pharmacol. 1978 Dec 18;14(6):445-7. doi: 10.1007/BF00716388.
Activated charcoal is known to reduce the absorption of therapeutic doses of nortriptyline in vivo when administered 30 min after drug ingestion. In a group of volunteers, one sachet (10 g) of a new activated charcoal preparation, 'Medicoal' was found to produce a highly significant reduction in nortriptyline absorption when given as long as four hours after nortriptyline dosing. Activated charcoal may therefore be useful in the treatment of tricyclic antidepressant poisoning even if a delay of several hours ensues before medical help is sought.
已知活性炭在摄入药物30分钟后给药时，可降低体内治疗剂量的去甲替林的吸收。在一组志愿者中，发现一袋（10克）新的活性炭制剂“Medicoal”，即使在去甲替林给药后长达四小时服用，也能显著降低去甲替林的吸收。因此，即使在寻求医疗帮助前有几个小时的延迟，活性炭也可能有助于三环类抗抑郁药中毒的治疗。
