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胎羊胆总管结扎:一种用于研究胆道闭锁的实验模型。

Ligation of the common bile duct in the fetal lamb: an experimental model for the study of biliary atresia.

作者信息

Spitz L

出版信息

Pediatr Res. 1980 May;14(5):740-8. doi: 10.1203/00006450-198005000-00007.

DOI:10.1203/00006450-198005000-00007
PMID:7383750
Abstract

Intrauterine ligation of the common bile duct was carried out in ten fetal lambs at approximately 80 days gestational age. Six of the fetal lambs survived until term and were sacrificed at varying periods until the 36th day of life. The lesion which developed resembled a "correctable" type of extrahepatic biliary atresia [Kasai type I (b)]. The lining epithelium was either totally or incompletely denuded in the blind end of the common duct proximal to the obstruction.

摘要

在大约妊娠80天时,对10只胎羊进行了宫内胆总管结扎。其中6只胎羊存活至足月,并在出生后不同时期直至出生后第36天被处死。所形成的病变类似于一种“可矫正”型肝外胆道闭锁[Kasai I型(b)]。在梗阻近端胆总管盲端,内衬上皮要么完全缺失,要么部分缺失。

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