Douglas A N
Thorax. 1980 Mar;35(3):198-201. doi: 10.1136/thx.35.3.198.
Histological sections from 30 lower lobe bronchi, taken from coalminers' lungs collected for the British National Coal Board's Pneumoconiosis Field Research, were selected according to the proportion of mucous gland area occupying the non-cartilaginous part of the bronchial wall. The total gland area expressed as a percentage of the non-cartilaginous wall was called the gland index. Estimations were made of the total number of gland cells and acini on a section and of their numbers per unit area of gland. These estimations were compared with the gland index. The total numbers of gland cells and acini were found to be directly related to the gland index (r=0.84 and 0.86), whereas no relationship was found between the number of gland cells or acini per unit area of gland and the gland index (r=0.08 and 0.02). This indicates that bronchial mucous gland enlargement is primarily a hyperplastic change. A direct relationship between the numbers of gland cells per unit area of gland and acini per unit area gland was found (r=0.69), and this suggests that acinar enlargement is likely to be caused by accumulation of mucus in the acinar lumen.
从为英国国家煤炭委员会尘肺病现场研究收集的矿工肺中选取30个下叶支气管的组织切片，根据黏液腺面积占支气管壁非软骨部分的比例进行选择。将腺体总面积表示为非软骨壁的百分比，称为腺体指数。对切片上的腺细胞和腺泡总数及其每单位腺体面积的数量进行了估计。将这些估计值与腺体指数进行比较。发现腺细胞和腺泡的总数与腺体指数直接相关（r = 0.84和0.86），而每单位腺体面积的腺细胞或腺泡数量与腺体指数之间未发现相关性（r = 0.08和0.02）。这表明支气管黏液腺肿大主要是一种增生性变化。发现每单位腺体面积的腺细胞数量与每单位腺体面积的腺泡数量之间存在直接关系（r = 0.69），这表明腺泡肿大可能是由于腺泡腔内黏液积聚所致。
