结直肠癌动物模型：从自发模型到基因工程模型及其应用

Nascimento-Gonçalves Elisabete, Mendes Bruno A L, Silva-Reis Rita, Faustino-Rocha Ana I, Gama Adelina, Oliveira Paula A

Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.

Department of Zootechnics, School of Sciences and Technology, University of Évora, 7000-812 Évora, Portugal.

Vet Sci. 2021 Apr 5;8(4):59. doi: 10.3390/vetsci8040059.

Colorectal cancer is one of the most common gastrointestinal malignancies in humans, affecting approximately 1.8 million people worldwide. This disease has a major social impact and high treatment costs. Animal models allow us to understand and follow the colon cancer progression; thus, in vivo studies are essential to improve and discover new ways of prevention and treatment. Dietary natural products have been under investigation for better and natural prevention, envisioning to show their potential. This manuscript intends to provide the readers a review of rodent colorectal cancer models available in the literature, highlighting their advantages and disadvantages, as well as their potential in the evaluation of several drugs and natural compounds' effects on colorectal cancer.

结直肠癌是人类最常见的胃肠道恶性肿瘤之一，全球约有180万人受其影响。这种疾病具有重大的社会影响和高昂的治疗成本。动物模型使我们能够了解并跟踪结肠癌的进展；因此，体内研究对于改进和发现新的预防与治疗方法至关重要。食用天然产物一直在被研究以寻求更好的天然预防方法，并展现其潜力。本手稿旨在为读者综述文献中可用的啮齿动物结直肠癌模型，突出它们的优缺点，以及它们在评估几种药物和天然化合物对结直肠癌的作用方面的潜力。