Walker W R, Beveridge S J, Whitehouse M W
Agents Actions. 1980 Apr;10(1 Pt 2):38-47. doi: 10.1007/BF02024177.
In rats, dermal (dorsum) application of an ethanolic copper salicylate complex (ECS) in ethanol with glycerol (Alcusal) effectively suppressed established polyarthritis, carrageenan-induced paw oedema and the inflammatory response to hydroxylapatite microcrystals. These responses appear to be due to some degree of synergism between the copper(II) and salicylate, i.e. not solely due to either species alone. Evidence for transdermal absorption of 64Cu from 64Cu-ECS is provided. Some safety aspects of this novel drug are discussed.
在大鼠中，将乙醇水杨酸铜络合物（ECS）与甘油在乙醇中配制成的溶液（Alcusal）经皮（背部）给药，可有效抑制已形成的多关节炎、角叉菜胶诱导的爪肿胀以及对羟基磷灰石微晶的炎症反应。这些反应似乎是由于铜（II）和水杨酸之间存在一定程度的协同作用，即并非仅由单一成分所致。文中提供了64Cu-ECS经皮吸收64Cu的证据。还讨论了这种新型药物的一些安全性问题。
