Donlon P T, Hopkin J T, Tupin J P, Wicks J J, Wahba M, Meadow A
Arch Gen Psychiatry. 1980 Jun;37(6):691-5. doi: 10.1001/archpsyc.1980.01780190089011.
The relative efficacy of three oral regimens of haloperidol was compared in a ten-day, double-blind study of 63 acutely ill schizophrenic patients newly admitted to the hospital. One group of patients received 20 mg of haloperidol on day 1, then increasing increments of 20 mg a day, reaching a maximum dosage of 100 mg daily on day 5. Another group received 10 mg of haloperidol on day 1, then increasing increments of 10 mg daily, reaching 100 mg daily on day 10. A third group of patients received a fixed dosage of 10 mg daily for ten days. Haloperidol was well tolerated by the patients; there were no serious adverse reactions. The data indicated that the regimens had similar therapeutic efficacy, suggesting that acutely ill schizophrenic patients respond to a wide range of doses of haloperidol but that onset of response and efficacy are not increased in most patients by providing a high initial loading dosage. Adequate, safe dosage must be determined in each case.
在一项针对63名新入院的急性精神分裂症患者的为期十天的双盲研究中，比较了三种口服氟哌啶醇方案的相对疗效。一组患者在第1天接受20毫克氟哌啶醇，然后每天增加20毫克，在第5天达到每日最大剂量100毫克。另一组在第1天接受10毫克氟哌啶醇，然后每天增加10毫克，在第10天达到每日100毫克。第三组患者连续十天接受每日10毫克的固定剂量。患者对氟哌啶醇耐受性良好；没有严重不良反应。数据表明这些方案具有相似的治疗效果，这表明急性精神分裂症患者对广泛剂量的氟哌啶醇都有反应，但在大多数患者中，通过提供高初始负荷剂量并不会增加反应的起始时间和疗效。必须针对每种情况确定足够、安全的剂量。
