Jenkins V K, Griffiths C M, Ray P, Perry R R, Olson M H
Arch Otolaryngol. 1980 Jul;106(7):414-8. doi: 10.1001/archotol.1980.00790310038009.
The mean number of lymphocytes, response to phytohemagglutinin (PHA), and response to concanavalin A (Con A) in whole-blood cultures for 106 patients with head and neck cancer were 83%, 73%, and 64%, respectively, of values for healthy control individuals. During radiotherapy, lymphocyte counts declined to 44% and PHA and Con A responses declined to about one third of control values. Lymphocyte counts slowly increased after treatment to 77% of control values after two years, but responses to mitogens remained at about 40%. Responses to PHA and Con A for 38 patients who lived beyond 18 months were significantly greater before and after treatment than responses for 39 patients who died within 18 months. In general, a poor pretreatment response to PHA and Con A correlated with a poor clinical course, whereas responses near the control level indicated a good clinical course.
106例头颈癌患者全血培养中淋巴细胞的平均数量、对植物血凝素（PHA）的反应以及对刀豆蛋白A（Con A）的反应分别为健康对照个体相应值的83%、73%和64%。在放疗期间，淋巴细胞计数降至44%，PHA和Con A反应降至对照值的约三分之一。治疗后淋巴细胞计数缓慢增加，两年后达到对照值的77%，但对有丝分裂原的反应仍保持在约40%。38例存活超过18个月的患者治疗前后对PHA和Con A的反应显著大于39例在18个月内死亡患者的反应。一般来说，治疗前对PHA和Con A的反应较差与临床病程较差相关，而接近对照水平的反应表明临床病程良好。
