Jenkins V K, Ray P, Ellis H N, Griffiths C M, Perry R R, Olson M H
Arch Otolaryngol. 1976 Oct;102(10):596-600. doi: 10.1001/archotol.1976.00780150064003.
Ffty-three patients with head and neck cancer tested before radiation treatment to determine numbers of blood lymphocytes and immunologic responses to mitogens of lymphocytes in whole-blood cultures had mean values that were 19% to 26% less than values for healthy individuals. Thirty patients whose disease was in stages III or IV had values similar to those in 23 patients whose disease was in stages I or II. Values for 45 patients tested at end of radiotherapy decreased to about 50% of pretreatment values; however, patients with advanced lesions experienced greater decreases (to 24% to 50%) than patients with localized lesions (to 71% to 84%). Patients with advanced lesions usually received radiation to larger areas than patients with localized lesions; therefore, the extent of decline in laboratory values was most likely dependent on volume of tissue treated.
53例头颈部癌患者在放疗前进行了检测，以确定血液淋巴细胞数量以及全血培养中淋巴细胞对有丝分裂原的免疫反应，其平均值比健康个体的值低19%至26%。30例疾病处于III期或IV期的患者的值与23例疾病处于I期或II期的患者的值相似。45例患者在放疗结束时检测的值降至治疗前值的约50%；然而，晚期病变患者的下降幅度（降至24%至50%）比局限性病变患者（降至71%至84%）更大。晚期病变患者通常比局限性病变患者接受放疗的面积更大；因此，实验室值下降的程度很可能取决于治疗组织的体积。
