Lamano Carvalho T L, Lopes R A, Azoubel R, Ferreira A L
Int J Vitam Nutr Res. 1978;48(4):316-24.
In a previous paper, Lamano Carvalho et al. [4] demonstrated that administration of excess vitamin A doses to adult rats causes decreased testicle mass, focal lesions in the seminal tubule epithelium, and reduction in the relative volume of interstitial tissue and in the nuclear volumes of Leydig cells. The hypervitaminotic animals also showed alterations in the rhythm of spermatogenesis and reduced hypophysary LH levels. In order to determine the possible reversibility of these alterations, the authors allowed the hypervitaminotic animals to recover for 50 or 100 days. After both recovery periods. the focal lesions in the germinal epithelium were still unreversed. On the other hand, the nuclear volume of Leydig cells and the rhythm of spermatogenesis, as well as hypophysary LH levels reverted to normal during the 50 day recovery period.
在之前的一篇论文中，拉马诺·卡瓦略等人[4]证明，给成年大鼠过量服用维生素A会导致睾丸质量下降、生精小管上皮出现局灶性病变，以及间质组织相对体积和莱迪希细胞的核体积减小。维生素A过量的动物还表现出精子发生节律改变和垂体促黄体生成素水平降低。为了确定这些改变的可能可逆性，作者让维生素A过量的动物恢复50天或100天。在两个恢复期后，生精上皮的局灶性病变仍然没有恢复。另一方面，在50天的恢复期内，莱迪希细胞的核体积、精子发生节律以及垂体促黄体生成素水平恢复到了正常。
