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一名患有华氏巨球蛋白血症性紫癜患者体内IgA与温度依赖性IgG复合物的形成

IgA and temperature dependent IgG complex formation in a patient with Waldenström's hypergammaglobulinaemic purpura.

作者信息

Roberts-Thomson P J, Kemp A S

出版信息

Clin Exp Immunol. 1980 Jan;39(1):164-9.

PMID:7389190
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537956/
Abstract

We describe a patient with hypergammaglobulinaemic purpura and show that the serum contains IgG and IgA immune complexes sedimenting between IgM and IgG on ultracentrifugation. The complexes containing IgG were markedly temperature dependent. A drop in temperature from 37 degrees C to 28 degrees C gave a seventeen-fold increase in the quantity of these complexes. This temperature dependency may be an important factor in localizing the major pathological manifestation of this disease to the skin.

摘要

我们描述了一位患有高球蛋白血症性紫癜的患者，并表明其血清中含有IgG和IgA免疫复合物，在超速离心时这些复合物沉降于IgM和IgG之间。含有IgG的复合物明显依赖温度。温度从37℃降至28℃会使这些复合物的量增加17倍。这种温度依赖性可能是将该疾病的主要病理表现定位于皮肤的一个重要因素。

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本文引用的文献

1
Gamma globulin complexes in rheumatoid arthritis and certain other conditions.类风湿关节炎及某些其他病症中的γ球蛋白复合物
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Occurrence of -globulin complexes in serum and joint fluid of rheumatoid arthritis patients: use of monoclonal rheumatoid factors as reagents for their demonstration.类风湿关节炎患者血清和关节液中γ球蛋白复合物的出现：使用单克隆类风湿因子作为检测试剂
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Benign hypergammaglobulinemic purpura of Waldenström.
Medicine (Baltimore). 1971 Mar;50(2):113-23. doi: 10.1097/00005792-197103000-00003.
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A case of purpura hyperglobulinaemica of Waldenström studied by skin immunofluorescence.
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Purpura hyperglobulinemia.高球蛋白血症性紫癜
Arch Dermatol. 1966 Nov;94(5):536-41.
6
Gamma globulin complexes in rheumatoid arthritis and hypergammaglobulinemic purpura.类风湿性关节炎和高丙种球蛋白血症性紫癜中的γ球蛋白复合物
J Rheumatol. 1974 Mar;1(1):54-65.
7
Characterization of an IgA rheumatoid factor: finding properties and reactivity with the subclasses of human G globulin.一种IgA类风湿因子的特性：发现其与人类γ球蛋白亚类的特性及反应性。
Immunochemistry. 1972 Mar;9(3):301-15. doi: 10.1016/0019-2791(72)90094-8.
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Hypergammaglobulinemic purpura. Studies on the unusual anti- -globulins characteristic of the sera of these patients.
Medicine (Baltimore). 1971 Mar;50(2):125-38.
9
Relationship between paraprotein polymerization and clinical features in IgA myeloma.IgA 骨髓瘤中副蛋白聚合与临床特征的关系
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The hyperviscosity syndrome in rheumatoid arthritis due to intermediate complexes formed by self-association of IgG-rheumatoid factors.类风湿关节炎中由IgG类风湿因子自缔合形成的中间复合物所致的高黏滞综合征。
Arthritis Rheum. 1975 Mar-Apr;18(2):97-106. doi: 10.1002/art.1780180201.