Dambuyant C, Thivolet J, Viala J J, Ville D, Boyer J
J Invest Dermatol. 1982 Mar;78(3):194-9. doi: 10.1111/1523-1747.ep12506441.
This study concerns 11 patients with immune complex associated cutaneous vasculitis (5 leukocytoclastic vasculitis or Gougerot Ruiter's disease, 3 essential mixed cryoglobulinaemia, 2 Henoch-Schönlein purpura and 1 Waldenström's hypergammaglobulinaemic purpura). By determining the clearance of 51Cr-labeled IgG sensitized erythrocytes we showed a slight modification in the splenic mononuclear phagocyte system. In patients with Gougerot-Ruiter's disease the clearance of the autologous IgG-coated erythrocytes was delayed in 1 patient, and normal in 2 patients. In contact, the 8 other patients showed accelerated rates of IgG-mediated clearance. There was no statistically significant correlation between clearance rate, serum complement component levels and composition and/or levels of circulating immune complexes. Thus, the accelerated clearance rate suggests an enhanced activity of the mononuclear phagocyte system IgG-Fc receptors.
本研究涉及11例免疫复合物相关性皮肤血管炎患者（5例白细胞破碎性血管炎或古热罗 - 鲁伊特病、3例原发性混合性冷球蛋白血症、2例过敏性紫癜和1例瓦尔登斯特伦高丙种球蛋白血症性紫癜）。通过测定51Cr标记的IgG致敏红细胞的清除率，我们发现脾单核吞噬细胞系统有轻微改变。在古热罗 - 鲁伊特病患者中，1例自体IgG包被红细胞的清除延迟，2例正常。相比之下，其他8例患者显示IgG介导的清除率加快。清除率、血清补体成分水平与循环免疫复合物的组成和/或水平之间无统计学显著相关性。因此，清除率加快提示单核吞噬细胞系统IgG - Fc受体活性增强。
