Stimson W H
Clin Exp Immunol. 1980 Apr;40(1):157-60.
Certain pregnancy-associated serum proteins, namely pregnancy-associated alpha 2-glycoprotein, pregnancy-specific beta 1-glycoprotein, alpha-foetoprotein, human placental lactogen and human chroionic gonadotrophin, have been proposed as immunosuppressive factors. A pregnancy serum was constructed from a number of such sera to produce high serum levels of these compounds. Each of the proteins was then removed sequentially from the serum by affinity chromatography and the remaining materials examined for inhibitory activity on lymphocyte transformation. Only the removal of pregnancy-associated alpha 2-glycoprotein decreased suppression by the serum. However, a large proportion of the serum inhibitory activity could not be accounted for, indicating the presence of other suppressor factors.
某些与妊娠相关的血清蛋白，即妊娠相关α2-糖蛋白、妊娠特异性β1-糖蛋白、甲胎蛋白、人胎盘催乳素和人绒毛膜促性腺激素，已被提出作为免疫抑制因子。从许多这样的血清中构建了一种妊娠血清，以产生这些化合物的高血清水平。然后通过亲和层析依次从血清中去除每种蛋白质，并检查剩余物质对淋巴细胞转化的抑制活性。只有去除妊娠相关α2-糖蛋白才会降低血清的抑制作用。然而，很大一部分血清抑制活性无法解释，这表明存在其他抑制因子。
