Philo L M
J Am Vet Med Assoc. 1978 Nov 1;173(9):1163-6.
Xylazine at dosages of 2.7 to 3.9 mg/kg of body weight was administered to 23 captive arctic wolves. The optimal dosage was higher for excited and socialized adults and lower for juveniles than for unexcited unsocialized adults. Mean time to initial effect was 2.5 minutes and mean time to sternal recumbency was 3.7 minutes. Maximal effect was achieved within 15 minutes, with adequate sedation lasting 30 to 60 minutes. Mean recovery time was longer for old (greater than 7-year-old) adults than for young (2- to 3-year-old) ones (2.4 vs 1.7 hours). Induction of and recovery from barbiturate anesthesia was smooth and quiet. Although a few adverse reactions were found, the use of xylazine with physical restraint was an excellent combination for many clinical procedures.
对23只圈养北极狼施用了剂量为2.7至3.9毫克/千克体重的赛拉嗪。兴奋且已驯化的成年狼的最佳剂量较高，幼狼的最佳剂量低于未兴奋且未驯化的成年狼。达到初始效果的平均时间为2.5分钟，达到胸卧姿势的平均时间为3.7分钟。15分钟内达到最大效果，充分镇静持续30至60分钟。老龄（大于7岁）成年狼的平均恢复时间比幼龄（2至3岁）成年狼长（2.4小时对1.7小时）。巴比妥类麻醉的诱导和恢复过程平稳且安静。尽管发现了一些不良反应，但赛拉嗪与身体约束配合使用对许多临床操作而言是一种极佳的组合。
