Jalanka H H
Clinical Department, College of Veterinary Medicine, Helsinki, Finland.
Acta Vet Scand. 1990;31(1):63-71. doi: 10.1186/BF03547578.
The sedative and immobilizing effects of the alpha 2-adrenoceptor agonist medetomidine alone or combined with the dissociative anesthetic ketamine, were studied in blue foxes. Medetomidine at doses of 25 and 50 micrograms/kg induced moderate to deep sedation, but only with the highest medetomidine dose tested, 100 micrograms/kg, was the immobilization complete. Medetomidine 50 micrograms/kg combined with ketamine 2.5 mg/kg rapidly induced complete immobilization, characterized by good myorelaxation, and no clinically significant alterations in serially determined hematologic and serum chemistry parameters. The alpha 2-adrenoceptor antagonist atipamezole effectively reversed the medetomidine- or medetomidine-ketamine-induced immobilizations. A transient increase in heart rates was noted after each atipamezole injection.
在蓝狐身上研究了α2-肾上腺素能受体激动剂美托咪定单独使用或与解离麻醉剂氯胺酮联合使用时的镇静和制动效果。25和50微克/千克剂量的美托咪定可诱导中度至深度镇静，但仅在测试的最高美托咪定剂量（100微克/千克）下制动才完全。50微克/千克的美托咪定与2.5毫克/千克的氯胺酮联合使用可迅速诱导完全制动，其特征为良好的肌肉松弛，并且连续测定的血液学和血清化学参数无临床显著变化。α2-肾上腺素能受体拮抗剂阿替美唑可有效逆转美托咪定或美托咪定-氯胺酮诱导的制动。每次注射阿替美唑后均观察到心率短暂升高。
