大鼠肝脏中钙离子依赖性中性蛋白酶抑制剂的存在。
The occurrence of an inhibitor of Ca2+-dependent neutral protease in rat liver.
作者信息
Nishiura I, Tanaka K, Yamato S, Murachi T
出版信息
J Biochem. 1978 Dec;84(6):1657-9. doi: 10.1093/oxfordjournals.jbchem.a132296.
Abstract
The occurrence of a novel and specific inhibitor of Ca2+-dependent neutral protease in rat liver has been demonstrated. The partially purified product is a heat-stable and acid-stable protein of an approximate molecular weight of 3x10(5), and readily inactivated by tryptic digestion. The inhibition of Ca2+-dependent protease is not a result of the binding of Ca2+ by the inhibitor.
摘要
已证实在大鼠肝脏中存在一种新型的、特异性的钙离子依赖性中性蛋白酶抑制剂。部分纯化的产物是一种热稳定且酸稳定的蛋白质，分子量约为3×10⁵，易被胰蛋白酶消化而失活。该抑制剂对钙离子依赖性蛋白酶的抑制作用并非由其与钙离子结合所致。
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