Cutilletta A F, Oparil S
Hypertension. 1980 May-Jun;2(3):304-10. doi: 10.1161/01.hyp.2.3.304.
Spontaneously hypertensive male rats (SHR) or normotensive Kyoto-Wistar (WKY) male rats underwent either sham or nerve growth factor antiserum (NGFAS) treatment during the first week of life. The NGFAS treatment prevented the development of hypertension in SHR but did not prevent the development of left ventricular groups in vivo under general anesthesia. After the recording of resting parameters, homologous whole blood was transfused until the rise in cardiac output reached a plateau. At rest, LV systolic pressure of the NGFAS-treated SHR was significantly lower than that of the sham-treated SHR and not statistically different from that of the WKY rat. The LV end diastolic pressures did not differ among the four groups. Both SHR groups had significantly lower cardiac, stroke, and contractility indices than di the WKY groups. Following vascular expansion, LV filling pressure, stroke index, and stroke work index rose in all groups. The response in the SHR was greater than that in WKY groups. Interestingly, the systolic pressure of the NGFAS-treated SHR rose to the same level as in the sham-treated SHR. Heart rate and calculated systemic vascular resistance fell following transfusion. The SHR appears to exhibit an altered response to increased filling pressure and increased afterload. Our findings are consistent with the concept of an alteration in the compliance of the LV in the SHR.
自发性高血压雄性大鼠（SHR）或血压正常的京都-威斯塔雄性大鼠（WKY）在出生后的第一周接受假手术或神经生长因子抗血清（NGFAS）治疗。NGFAS治疗可预防SHR高血压的发展，但在全身麻醉下并不能预防体内左心室肥大的发展。记录静息参数后，输注同源全血，直至心输出量上升至平台期。静息时，经NGFAS治疗的SHR的左心室收缩压显著低于假手术治疗的SHR，且与WKY大鼠无统计学差异。四组之间的左心室舒张末期压力无差异。两个SHR组的心脏、搏出量和收缩性指数均显著低于WKY组。血管扩张后，所有组的左心室充盈压、搏出指数和搏功指数均升高。SHR组的反应大于WKY组。有趣的是，经NGFAS治疗的SHR的收缩压升至与假手术治疗的SHR相同的水平。输血后心率和计算得出的全身血管阻力下降。SHR似乎对充盈压升高和后负荷增加表现出改变的反应。我们的研究结果与SHR左心室顺应性改变的概念一致。
