Toshniwal R, Fekety R, Silva J
Antimicrob Agents Chemother. 1979 Aug;16(2):167-70. doi: 10.1128/AAC.16.2.167.
Tetracyclines were implicated in the 1950s in induction of protracted diarrhea and pseudomembranous colitis. Because the pathogenetic mechanism of these illnesses has been questioned recently, we studied tetracycline in hamster models of antibiotic-associated colitis. Orogastric administration of tetracycline caused diarrhea and death, with evidence of hemorrhagic typhlitis. Filtrates of cecal contents were toxic when inoculated into normal hamsters and cell culture monolayers, and toxicity was neutralized with Clostridium sordellii antitoxin. Tetracycline-resistant C. difficile was cultured from stools of these hamsters, but Staphylococcus aureus was not isolated. The value of tetracycline for treatment or prevention of clindamycin-induced colitis in hamsters was also studied, and it was found that daily orogastric administration of tetracycline was poorly protective against clindamycin-induced colitis.
20世纪50年代认为四环素可引发持续性腹泻和假膜性结肠炎。由于最近对这些疾病的发病机制提出了质疑，我们在抗生素相关性结肠炎的仓鼠模型中研究了四环素。经口胃管给予四环素会导致腹泻和死亡，并伴有出血性盲肠炎的迹象。将盲肠内容物滤液接种到正常仓鼠和细胞培养单层中具有毒性，且毒性可用索氏梭菌抗毒素中和。从这些仓鼠的粪便中培养出了耐四环素的艰难梭菌，但未分离出金黄色葡萄球菌。还研究了四环素对治疗或预防仓鼠克林霉素诱导的结肠炎的价值，发现每日经口胃管给予四环素对克林霉素诱导的结肠炎的保护作用较差。
