Oleĭnikova E N, Shendereva T S
Arkh Patol. 1980;42(4):20-4.
Investigation of lymphogranulomatosis process in 42 patients included histological examinations of chains of lymph nodes with varying duration of their involvement. Lymphogranulomatosis was shown to begin with focal involvement of lymph nodes. The specific focus is initially located in the paracortical zone, then the pathological process extends into the medullary zone and finally into the cortical zone. As early and finally into the cortical zone. As early as the focal lesions occur the cell composition already corresponds to one of histological variants of lymphogranulomatosis (by Lukes' classification). No transition from variants with lymphoid prevalence to those with lymphoid exhaustion in groups of removed lymph nodes from the same patient was observed indicating independent development of each histological type and its stability for a given patient. No correlation between the clinical stage and morphological type of lymphogranulomatosis was established.
对42例淋巴肉芽肿病患者的研究包括对不同受累时长的淋巴结链进行组织学检查。结果显示，淋巴肉芽肿病始于淋巴结的局灶性受累。特定病灶最初位于副皮质区，随后病理过程扩展至髓质区，最终累及皮质区。早在局灶性病变出现时，细胞组成就已符合淋巴肉芽肿病的一种组织学类型（按照卢克斯分类法）。在同一患者切除的淋巴结组中，未观察到从淋巴细胞为主型向淋巴细胞耗竭型的转变，这表明每种组织学类型是独立发展的，且对于特定患者具有稳定性。淋巴肉芽肿病的临床分期与形态学类型之间未建立相关性。
